Rybelsus® – Possible Side Effects

Slim Clinic Patient Information

Rybelsus® (oral semaglutide) is an effective prescription treatment for blood sugar control and weight management. Like all medications, it can cause side effects, although not everyone will experience them. Understanding the possible reactions helps ensure safe and successful treatment.

⚠️ Serious Side Effects

Common (up to 1 in 10 people)

Diabetic eye disease complications (retinopathy)
If you notice visual changes or any eye problems while taking Rybelsus, inform your Slim Clinic doctor promptly.

Rare (up to 1 in 1,000 people)

Severe allergic reactions (anaphylaxis)
Seek emergency medical help if you experience:

  • Difficulty breathing

  • Swelling of the face, lips, or throat

  • Wheezing

  • Rapid heartbeat

  • Pale, clammy skin

  • Dizziness or extreme weakness

Acute pancreatitis (inflamed pancreas)
Symptoms may include:

  • Persistent, severe stomach pain (upper abdomen)

  • Pain radiating to the back

  • Nausea or vomiting
    Stop Rybelsus immediately and seek urgent medical care if these occur.

Other Side Effects

Very Common (more than 1 in 10 people)

  • Nausea – usually improves as your body adjusts

  • Diarrhoea – generally temporary

  • Low blood sugar (hypoglycaemia) when used with insulin or sulfonylureas

Recognising low blood sugar

Symptoms may include:
Cold sweats, pale skin, headache, fast heartbeat, nausea or strong hunger, blurry vision, tiredness, shaking, anxiety, nervousness, or difficulty concentrating.
Your Slim Clinic clinician may adjust your diabetes medication to reduce this risk.

Common (up to 1 in 10 people)

  • Vomiting

  • Low blood sugar when combined with certain diabetes medications

  • Upset stomach / digestive discomfort

  • Gastritis (stomach pain, nausea, vomiting)

  • Heartburn / acid reflux (GERD)

  • Stomach ache

  • Bloating

  • Constipation

  • Fatigue

  • Reduced appetite

  • Gas (flatulence)

  • Increased pancreatic enzymes (lipase, amylase) on blood tests

Occasional (up to 1 in 100 people)

  • Weight loss

  • Gallstones

  • Belching

  • Faster pulse

When to Contact Slim Clinic

You should speak to your doctor if:

  • Side effects are severe or persistent

  • You notice visual changes

  • Symptoms worsen after a dose change

  • You are experiencing signs of dehydration

  • You are unsure whether a symptom is normal

Seek emergency care if you experience:

  • Signs of pancreatitis

  • Severe allergic reactions

  • Fainting or extreme weakness